This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gopinath, R.
Right arrow Articles by Nutman, T. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gopinath, R.
Right arrow Articles by Nutman, T. B.

 Previous Article  |  Next Article 

Infection and Immunity, January 2000, p. 93-99, Vol. 68, No. 1
0019-9567/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Perturbations in Eosinophil Homeostasis following Treatment of Lymphatic Filariasis

Ramya Gopinath,1,* L. E. Hanna,2 V. Kumaraswami,2 V. Perumal,3 V. Kavitha,3 V. Vijayasekaran,3 and Thomas B. Nutman1

Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,1 and Tuberculosis Research Centre2 and Government General Hospital,3 Madras, India

Received 11 June 1999/Returned for modification 6 August 1999/Accepted 6 October 1999

Treatment of patients with patent Wuchereria bancrofti infection results in an acute clinical reaction and peripheral eosinophilia. To investigate the dynamics of the eosinophil response, changes in eosinophil activation and degranulation and plasma levels of eosinophil-active chemokines and cytokines were studied in 15 microfilaremic individuals in south India by sequential blood sampling before and after administration of 300 mg of diethylcarbamazine (DEC). Clinical symptoms occurred within 24 h. Plasma interleukin-5 (IL-5) and RANTES levels peaked 1 to 2 days posttreatment, preceding a peak peripheral eosinophil count at day 4. Major basic protein secretion from eosinophils paralleled IL-5 secretion, while levels of eosinophil-derived neurotoxin peaked at day 13 after treatment. Expression of the activation markers HLA-DR and CD25 on eosinophils rose markedly immediately after treatment, while expression of VLA-4 and alpha 4beta 7 showed an early peak within 24 h and a second peak at day 13. Thus, the posttreatment reactions seen in filarial infections can be divided into an early phase with killing of microfilariae, clinical symptomatology, increases in plasma IL-5 and RANTES levels, and eosinophil activation and degranulation and a later phase with expression of surface integrins on eosinophils, recruitment of eosinophils from the bone marrow to tissues, and clearance of parasite antigen.

* Corresponding author. Mailing address: LPD, NIAID, Building 4, Room 126, NIH, Bethesda, MD 20892. Phone: (301) 496-3449. Fax: (301) 480-3757. E-mail: rgopinath{at}niaid.nih.gov.

Infection and Immunity, January 2000, p. 93-99, Vol. 68, No. 1
0019-9567/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Reimert, C. M., Fitzsimmons, C. M., Joseph, S., Mwatha, J. K., Jones, F. M., Kimani, G., Hoffmann, K. F., Booth, M., Kabatereine, N. B., Dunne, D. W., Vennervald, B. J. (2006). Eosinophil Activity in Schistosoma mansoni Infections In Vivo and In Vitro in Relation to Plasma Cytokine Profile Pre- and Posttreatment with Praziquantel.. CVI 13: 584-593 [Abstract] [Full Text]  
  • Fitzsimmons, C. M., Joseph, S., Jones, F. M., Reimert, C. M., Hoffmann, K. F., Kazibwe, F., Kimani, G., Mwatha, J. K., Ouma, J. H., Tukahebwa, E. M., Kariuki, Henry. C., Vennervald, B. J., Kabatereine, N. B., Dunne, D. W. (2004). Chemotherapy for Schistosomiasis in Ugandan Fishermen: Treatment Can Cause a Rapid Increase in Interleukin-5 Levels in Plasma but Decreased Levels of Eosinophilia and Worm-Specific Immunoglobulin E. Infect. Immun. 72: 4023-4030 [Abstract] [Full Text]  
  • O'Bryan, L., Pinkston, P., Kumaraswami, V., Vijayan, V., Yenokida, G., Rosenberg, H. F., Crystal, R., Ottesen, E. A., Nutman, T. B. (2003). Localized Eosinophil Degranulation Mediates Disease in Tropical Pulmonary Eosinophilia. Infect. Immun. 71: 1337-1342 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»