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Infection and Immunity, October 2000, p. 6034-6037, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Immunization with Recombinant Plasmodium yoelii Merozoite Surface Protein 4/5 Protects Mice against Lethal Challenge

Lukasz Kedzierski, Casilda G. Black, and Ross L. Coppel*

Department of Microbiology, Monash University 3800, Victoria, Australia

Received 13 March 2000/Returned for modification 8 May 2000/Accepted 28 June 2000

Plasmodium yoelii merozoite surface protein 4/5 (PyMSP4/5), expressed as a recombinant protein, was highly effective at protecting mice against lethal challenge with P. yoelii. There was a significant correlation between prechallenge antibody levels and peak parasitemia, suggesting that the homologues of PyMSP4/5 in Plasmodium falciparum are promising components of a subunit vaccine against malaria.

* Corresponding author. Mailing address: Department of Microbiology, P.O. Box 53, Monash University 3800, Victoria, Australia. Phone: 61-3-9905-4822. Fax: 61-3-9905-4811. E-mail: ross.coppel{at}med.monash.edu.au.

Infection and Immunity, October 2000, p. 6034-6037, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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