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Infection and Immunity, October 2000, p. 6038-6040, Vol. 68, No. 10
Department of Microbiology, Montana State
University, Bozeman, Montana 59717
Received 24 April 2000/Returned for modification 15 June
2000/Accepted 29 June 2000
Gamma interferon (IFN-
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Differential Sensitivities of Chlamydia
trachomatis Strains to Inhibitory Effects of Gamma
Interferon
) is an important cytokine in host defense
against chlamydial infection. An in vitro cell culture system was used
to show that IFN-
inhibition of chlamydial growth, as determined by
diminished recovery of infectious elementary bodies, differed markedly
among chlamydial strains. These differences in sensitivity among
chlamydial strains to IFN-
-mediated inhibition may profoundly
influence the clinical outcome of infection.
*
Mailing address: Department of Microbiology, Lewis
Hall, Room 109, Montana State University, Bozeman, MT 59717. Phone:
(406) 994-7959. Fax: (406) 994-7959. E-mail:
morrison{at}montana.edu.
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