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Infection and Immunity, October 2000, p. 6041-6043, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors

Mark Roberts,1,* Steven Chatfield,2,dagger Derek Pickard,2 Jingli Li,2 and Andrew Bacon2

Department of Veterinary Pathology, Glasgow University Veterinary School, Glasgow G61 1QH,1 and Vaccine Research Unit, Medeva, Department of Biochemistry, Imperial College of Science, Technology, and Medicine, London SW7 2AZ,2 United Kingdom

Received 10 April 2000/Returned for modification 5 June 2000/Accepted 28 June 2000

We compared the ability of Salmonella enterica serovar Typhimurium SL1344 aroA aroD (BRD509) and aroA htrA (BRD807) mutants to act as live vectors for delivery of fragment C of tetanus toxin (FrgC). FrgC was expressed in these strains from either pTETnir15 or pTEThtrA1. BRD509FrgC+ strains elicited ~2-log-higher serum anti-FrgC antibody titers than BRD807FrgC+ strains. All mice immunized with BRD807pTEThtrA1, BRD509pTEThtrA1, and BRD509pTETnir15 (but not BRD807pTETnir15) were protected against tetanus.

* Corresponding author. Mailing address: Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Rd., Glasgow G61 1QH, United Kingdom. Phone: 0141-330-5780. Fax: 0141-330-5602. E-mail: M.Roberts{at}vet.gla.ac.uk.

dagger Present address: Microscience, ICSM Hammersmith Campus, London, W12 0NN, United Kingdom.

Infection and Immunity, October 2000, p. 6041-6043, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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