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Infection and Immunity, October 2000, p. 6048-6051, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Identification of Lipoprotein Homologues of Pneumococcal PsaA in the Equine Pathogens Streptococcus equi and Streptococcus zooepidemicus

Dean J. Harrington,1,* Joanne S. Greated,1 Neil Chanter,2 and Iain C. Sutcliffe1

School of Sciences, University of Sunderland, Sunderland,1 and Animal Health Trust, Newmarket,2 United Kingdom

Received 6 July 1999/Returned for modification 2 August 1999/Accepted 26 July 2000

Streptococcus equi and Streptococcus zooepidemicus are major etiological agents of upper and lower airway disease in horses. Despite the considerable animal suffering and economic burden associated with these diseases, the factors that contribute to the virulence of these equine pathogens have not been extensively investigated. Here we demonstrate the presence of a homologue of the Streptococcus pneumoniae PsaA protein in both of these equine pathogens. Inhibition of signal peptide processing by the antibiotic globomycin confirmed the lipoprotein nature of the mature proteins, and surface exposure was confirmed by their release from intact cells by mild trypsinolysis.

* Corresponding author. Mailing address: Fleming Building, School of Sciences, The University of Sunderland, Sunderland SR2 3SD, United Kingdom. Phone: 44 191 515 2995. Fax: 44 191 515 3747. E-mail: dean.harrington{at}sunderland.ac.uk.

Infection and Immunity, October 2000, p. 6048-6051, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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