Infection and Immunity, October 2000, p. 6073-6076, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany,1 and Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York2
Received 18 April 2000/Returned for modification 12 May 2000/Accepted 16 July 2000
Numbers of gamma interferon (IFN-
)-producing cells reactive to
ESAT-6 antigen were increased in recent converters to purified protein
derivative positivity and in tuberculosis patients but not in
unvaccinated or Mycobacterium bovis BCG-vaccinated healthy donors. ESAT-6-reactive IFN-
-producing cells in recent converters and tuberculosis patients recognized similar synthetic peptides. Thus,
ESAT-6 is a potential candidate for use in detection of early, as well
as active, tuberculosis and for control of the disease.
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