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Infection and Immunity, November 2000, p. 6457-6460, Vol. 68, No. 11
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Evidence for Vaccine Synergy between Borrelia burgdorferi Decorin Binding Protein A and Outer Surface Protein A in the Mouse Model of Lyme Borreliosis

Mark S. Hanson,* Nita K. Patel, David R. Cassatt, and Nancy D. Ulbrandt

MedImmune, Inc., Gaithersburg, Maryland 20878

Received 14 April 2000/Returned for modification 12 June 2000/Accepted 24 August 2000

Mice immunized with either the predominantly vector-stage lipoprotein outer surface protein A (OspA) or the in vivo-expressed lipoprotein decorin binding protein A (DbpA) are protected against Borrelia burgdorferi challenge. DbpA-OspA combinations protected against 100-fold-higher challenge doses than did either single-antigen vaccine and conferred significant protection against heterologous B. burgdorferi, B. garinii, and B. afzelii isolates, suggesting that there is synergy between these two immunogens.

* Corresponding author. Mailing address: MedImmune, Inc., 35 W. Watkins Mill Rd., Gaithersburg, MD 20878. Phone: (301) 527-4264. Fax: (301) 527-4200. E-mail: hansonm{at}medimmune.com.

Infection and Immunity, November 2000, p. 6457-6460, Vol. 68, No. 11
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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