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Infection and Immunity, November 2000, p. 6478-6481, Vol. 68, No. 11
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Inhibition of Chlamydia pneumoniae Replication in Human Aortic Smooth Muscle Cells by Gamma Interferon-Induced Indoleamine 2,3-Dioxygenase Activity

Laura G. Pantoja,1,2 Richard D. Miller,2 Julio A. Ramirez,1 Robert E. Molestina,1 and James T. Summersgill1,2,*

Division of Infectious Diseases, Department of Medicine,1 and Department of Microbiology and Immunology,2 University of Louisville School of Medicine, Louisville, Kentucky 40292

Received 20 April 2000/Returned for modification 31 May 2000/Accepted 24 August 2000

Infection with Chlamydia pneumoniae, a human respiratory pathogen, has been implicated as a potential risk factor in atherosclerosis, possibly because the pathogen can exist in a persistent form similar to that described for Chlamydia trachomatis. The present study investigated whether gamma interferon (IFN-gamma ) can induce indoleamine 2,3-dioxygenase (IDO) activity in aortic smooth muscle cells, leading to a marked inhibition of C. pneumoniae growth. Our data indicate a stimulation of IDO mRNA expression and dose-dependent enzymatic activity following IFN-gamma treatment. IDO-mediated increase in tryptophan catabolism resulted in a dose-dependent marked inhibition of C. pneumoniae replication.

* Corresponding author. Mailing address: Division of Infectious Diseases, MDR Building, Room 612, Department of Medicine, University of Louisville, Louisville, KY 40292. Phone: (502) 852-5132. Fax: (502) 852-1147. E-mail: jtsumm{at}louisville.edu.

Infection and Immunity, November 2000, p. 6478-6481, Vol. 68, No. 11
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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