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Infection and Immunity, November 2000, p. 6505-6508, Vol. 68, No. 11
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Latency-Associated Peptide of Transforming Growth Factor beta  Enhances Mycobacteriocidal Immunity in the Lung during Mycobacterium bovis BCG Infection in C57BL/6 Mice

K. A. Wilkinson,1,dagger T. D. Martin,1,Dagger S. M. Reba,1 H. Aung,1 R. W. Redline,2 W. H. Boom,1 Z. Toossi,1 and S. A. Fulton1,*

Division of Infectious Diseases1 and the Institute of Pathology,2 Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106-4984

Received 22 May 2000/Returned for modification 18 July 2000/Accepted 24 August 2000

Latency-associated peptide of transforming growth factor beta  (TGF-beta ) (LAP) was used to determine whether in vivo modulation of TGF-beta bioactivity enhanced pulmonary immunity to Mycobacterium bovis BCG infection in C57BL/6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferation and gamma interferon mRNA expression. Thus, susceptibility of the lung to primary BCG infection may be partially mediated by the immunosuppressive effects of TGF-beta .

* Corresponding author. Mailing address: Division of Infectious Diseases, Case Western Reserve University, Biomedical Research Building 1010B, 10900 Euclid Ave., Cleveland, OH 44106-4984. Phone: (216) 368-8900. Fax: (216) 368-2034. E-mail: sxf24{at}po.cwru.edu.

dagger Present address: Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

Dagger Present address: National Cancer Institute, Frederick, MD 21702.

Infection and Immunity, November 2000, p. 6505-6508, Vol. 68, No. 11
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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