This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boelens, J. J.
Right arrow Articles by Dankert, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boelens, J. J.
Right arrow Articles by Dankert, J.

 Previous Article  |  Next Article 

Infection and Immunity, December 2000, p. 6924-6931, Vol. 68, No. 12
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Interleukin-1 Receptor Type I Gene-Deficient Mice Are Less Susceptible to Staphylococcus epidermidis Biomaterial-Associated Infection than Are Wild-Type Mice

Jaap Jan Boelens,1,* Tom van der Poll,2 Sebastian A. J. Zaat,3 Jean L. A. N. Murk,3 Jan J. Weening,4 and Jacob Dankert3

Department of Pediatrics, Leiden University Medical Center, 2300 RC, Leiden,1 and Department of Medical Microbiology,3 Department of Experimental Internal Medicine,2 and Department of Pathology,4 Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands

Received 8 March 2000/Returned for modification 24 April 2000/Accepted 24 August 2000

Elevated concentrations of interleukin-1 (IL-1) were found in tissue surrounding biomaterials infected with Staphylococcus epidermidis. To determine the role of IL-1 in biomaterial-associated infection (BAI), IL-1 receptor type I-deficient (IL-1R-/-) and wild-type mice received subcutaneous implants of silicon elastomer (SE) or polyvinylpyrrolidone-grafted SE (SEpvp), combined with an injection of 106 CFU of S. epidermidis or sterile saline. Neither mouse strain was susceptible to BAI around SE. IL-1R-/- mice with SEpvp implants had a no abscess formation and a reduced susceptibility to persistent S. epidermidis infection. The normal foreign body response, characterized by giant-cell formation and encapsulation, was delayed around SEpvp in wild-type mice but not in IL-1R-/- mice. This coincided with enhanced local IL-4 production in IL-1R-/- mice. These data suggest that inhibition of local IL-1 activity may be beneficial for the outcome of BAI.

* Corresponding author. Mailing address: Dept. of Pediatrics, P.O. Box 9600, J6-Q-208, 2300 RC Leiden, The Netherlands. Phone: 31 71 5262824. Fax: 31 71 5248198. E-mail: boelensjj{at}yahoo.com.

Infection and Immunity, December 2000, p. 6924-6931, Vol. 68, No. 12
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Schultz, M. J., Rijneveld, A. W., Florquin, S., Edwards, C. K., Dinarello, C. A., van der Poll, T. (2002). Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L285-L290 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»