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Infection and Immunity, December 2000, p. 7159-7161, Vol. 68, No. 12
Institute of Clinical Microbiology,
Immunology and Hygiene, University of Erlangen, 91054 Erlangen,
Germany,1 and Eukaryotic Genetics Group,
National Research Council of Canada, Biotechnology Research
Institute, Montreal, Quebec, Canada H4P 2R22
Received 26 June 2000/Returned for modification 30 August
2000/Accepted 25 September 2000
Cpp1p is a putative mitogen-activated protein (MAP) kinase
phosphatase that suppresses Candida albicans hyphal
formation at 25°C through its probable substrate, the Cek1p
filamentation MAP kinase. Here we report that expression of the
serum-induced genes SAP4-6 and HYR1 increased
several fold in hyphal forms of a cpp1/cpp1 null mutant,
while the rate and extent of hyphal development up to 5 h were
normal. Therefore, we provide evidence that Cpp1p represses hyphal gene
expression by acting through a Cek1p-independent mechanism.
SAP4-6 and HYR1 transcripts were undetectable
in a null mutant of another key regulator of filamentation, Efg1p; thus, Efg1p and Cpp1p oppose each other during the expression of these
genes in hyphal forms.
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Repression of Hyphal Proteinase Expression by the
Mitogen-Activated Protein (MAP) Kinase Phosphatase Cpp1p of
Candida albicans Is Independent of the MAP Kinase
Cek1p
*
Corresponding author. Mailing address: Institute of
Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstraße 3, 91054 Erlangen, Germany. Phone: 49 9131 852 2552. Fax: 49 9131 852 2573. E-mail:
klaus.schroeppel{at}mikrobio.med.uni-erlangen.de.
Present address: Proteome, Inc., Beverly, MA 01915.
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