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Infection and Immunity, December 2000, p. 7159-7161, Vol. 68, No. 12
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Repression of Hyphal Proteinase Expression by the Mitogen-Activated Protein (MAP) Kinase Phosphatase Cpp1p of Candida albicans Is Independent of the MAP Kinase Cek1p

Klaus Schröppel,1,* Katrin Sprößer,1 Malcolm Whiteway,2 David Y. Thomas,2 Martin Röllinghoff,1 and Csilla Csank2,dagger

Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, 91054 Erlangen, Germany,1 and Eukaryotic Genetics Group, National Research Council of Canada, Biotechnology Research Institute, Montreal, Quebec, Canada H4P 2R22

Received 26 June 2000/Returned for modification 30 August 2000/Accepted 25 September 2000

Cpp1p is a putative mitogen-activated protein (MAP) kinase phosphatase that suppresses Candida albicans hyphal formation at 25°C through its probable substrate, the Cek1p filamentation MAP kinase. Here we report that expression of the serum-induced genes SAP4-6 and HYR1 increased several fold in hyphal forms of a cpp1/cpp1 null mutant, while the rate and extent of hyphal development up to 5 h were normal. Therefore, we provide evidence that Cpp1p represses hyphal gene expression by acting through a Cek1p-independent mechanism. SAP4-6 and HYR1 transcripts were undetectable in a null mutant of another key regulator of filamentation, Efg1p; thus, Efg1p and Cpp1p oppose each other during the expression of these genes in hyphal forms.

* Corresponding author. Mailing address: Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstraße 3, 91054 Erlangen, Germany. Phone: 49 9131 852 2552. Fax: 49 9131 852 2573. E-mail: klaus.schroeppel{at}mikrobio.med.uni-erlangen.de.

dagger Present address: Proteome, Inc., Beverly, MA 01915.

Infection and Immunity, December 2000, p. 7159-7161, Vol. 68, No. 12
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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Copyright © 2000 by the American Society for Microbiology. All rights reserved.