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Infection and Immunity, February 2000, p. 960-964, Vol. 68, No. 2
Department of Vaccines, National Public
Health Institute,1 and Department of
Pathology, National Veterinary and Food Research
Institute,2 Helsinki, Finland
Received 6 May 1999/Returned for modification 21 July 1999/Accepted 9 November 1999
The role of gamma interferon (IFN-
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Acquired Immunity to Chlamydia
pneumoniae Is Dependent on Gamma Interferon in Two Mouse Strains
That Initially Differ in This Respect after Primary Challenge

) in a Chlamydia
pneumoniae mouse model was studied by in vivo neutralization in
two inbred mouse strains. During primary C. pneumoniae
infection, neutralization of IFN-
increased both the numbers of
bacteria and the pneumonia score in the lungs of C57BL/6 mice but not
BALB/c mice. During reinfection, the bacterial counts in the lungs were
increased by IFN-
neutralization in both mouse strains. Thus, the
effect of IFN-
neutralization was dependent on the genetic
background in primary infection. However, IFN-
appeared to be
equally important in both mouse strains during reinfection.
*
Corresponding author. Present address: Cultor
Corporation, Technology Center, FIN-02460 Kantvik, Finland. Phone:
358-9-297 4512. Fax: 368-9-298 2203. E-mail:
nina.rautonen{at}cultor.fi.
Previously published as Jenni M. Penttilä.
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