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Infection and Immunity, February 2000, p. 960-964, Vol. 68, No. 2
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Acquired Immunity to Chlamydia pneumoniae Is Dependent on Gamma Interferon in Two Mouse Strains That Initially Differ in This Respect after Primary Challenge

Jenni M. Vuola,1,dagger Vuokko Puurula,2 Marjukka Anttila,2 P. Helena Mäkelä,1 and Nina Rautonen1,*

Department of Vaccines, National Public Health Institute,1 and Department of Pathology, National Veterinary and Food Research Institute,2 Helsinki, Finland

Received 6 May 1999/Returned for modification 21 July 1999/Accepted 9 November 1999

The role of gamma interferon (IFN-gamma ) in a Chlamydia pneumoniae mouse model was studied by in vivo neutralization in two inbred mouse strains. During primary C. pneumoniae infection, neutralization of IFN-gamma increased both the numbers of bacteria and the pneumonia score in the lungs of C57BL/6 mice but not BALB/c mice. During reinfection, the bacterial counts in the lungs were increased by IFN-gamma neutralization in both mouse strains. Thus, the effect of IFN-gamma neutralization was dependent on the genetic background in primary infection. However, IFN-gamma appeared to be equally important in both mouse strains during reinfection.

* Corresponding author. Present address: Cultor Corporation, Technology Center, FIN-02460 Kantvik, Finland. Phone: 358-9-297 4512. Fax: 368-9-298 2203. E-mail: nina.rautonen{at}cultor.fi.

dagger Previously published as Jenni M. Penttilä.

Infection and Immunity, February 2000, p. 960-964, Vol. 68, No. 2
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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