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Infection and Immunity, February 2000, p. 965-968, Vol. 68, No. 2
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Candida albicans-Derived beta -1,2-Linked Mannooligosaccharides Induce Desensitization of Macrophages

Thierry Jouault,* Chantal Fradin, Pierre-André Trinel, and Daniel Poulain

Laboratoire de Mycologie Fondamentale et Appliquée, INSERM E9915, Université de Lille II, Faculté de Médecine H. Warembourg, Lille, France

Received 28 June 1999/Returned for modification 7 September 1999/Accepted 28 October 1999

Candida albicans beta -1,2-oligomannosides stimulate macrophage tumor necrosis factor alpha (TNF-alpha ) but not NO release. This stimulation desensitized macrophages by altering beta -1,2-oligomannoside-dependent TNF-alpha production and lipopolysaccharide-dependent TNF-alpha and NO secretion. Desensitization was not related to tyrosine phosphorylation signal transduction but was transferred by culture supernatants in which arachidonic acid derivatives were evidenced.

* Corresponding author. Mailing address: Laboratoire de Mycologie Fondamentale et Appliquée, INSERM E9915, Université de Lille II, Faculté de Médecine H. Warembourg, Pôle Recherche, Place Verdun, 59037 Lille, France. Phone: (33) 3 20 47 26 29. Fax: (33) 3 20 47 26 25. E-mail: tjou{at}worldnet.fr.

Infection and Immunity, February 2000, p. 965-968, Vol. 68, No. 2
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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