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Infection and Immunity, February 2000, p. 973-976, Vol. 68, No. 2
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Two Allelic Forms of the Aureolysin Gene (aur) within Staphylococcus aureus

Artur Sabat,1 Klaudia Kosowska,1 Knud Poulsen,2 Andrzej Kasprowicz,3 Agnieszka Sekowska,4 Bertus van den Burg,5 James Travis,6 and Jan Potempa1,6,*

Department of Microbiology and Immunology, Institute of Molecular Biology, Jagiellonian University, 31-120 Krakow,1 and Center of Microbiological Research and Autovaccines, 31-016 Krakow,3 Poland; Department of Medical Microbiology and Immunology, University of Aarhus, DK-8000 Aarhus, Denmark2; Institut Pasteur Unite Regulation de l'Expression Genetique, 75724 Paris, France4; Department of Genetics, Groningen Sciences and Biotechnology Institute, Haren, The Netherlands5; and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 306026

Received 8 September 1999/Returned for modification 19 October 1999/Accepted 18 November 1999

Proteinases of Staphylococcus aureus are emerging as potential virulence factors which may be involved in the pathogenecity of staphylococcal diseases. We describe here the structure of the gene encoding the metalloproteinase referred to as aureolysin. This gene occurs in two allelic forms and is strongly conserved among S. aureus strains, implying the possibility that the proteinase may have important housekeeping functions.

* Corresponding author. Mailing address: Jagiellonian University, Institute of Molecular Biology, Department of Microbiology and Immunology, Al. Mickiewicza 3, 31-120 Krakow, Poland. Phone: (48-12) 634-1442. Fax: (48-12) 633-6907. E-mail: potempa{at}mol.uj.edu.pl.

Infection and Immunity, February 2000, p. 973-976, Vol. 68, No. 2
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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