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Infection and Immunity, February 2000, p. 994-998, Vol. 68, No. 2
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Human Monocyte Receptors Involved in Tumor Necrosis Factor Responses to Group B Streptococcal Products

Maria Cuzzola,1 Giuseppe Mancuso,1 Concetta Beninati,1 Carmelo Biondo,1 Christina von Hunolstein,2 Graziella Orefici,2 Terje Espevik,3 Trude H. Flo,3 and Giuseppe Teti1,*

Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università degli Studi di Messina, I-98125 Messina,1 and Laboratorio di Micologia e Batteriologia, Istituto Superiore di Sanità, I-00143 Rome,2 Italy, and Institute for Cancer Research, University of Trondheim, 7489 Trondheim, Norway3

Received 24 June 1999/Returned for modification 26 August 1999/Accepted 29 October 1999

Several group B streptococcal products have been previously found to stimulate human monocytes to produce tumor necrosis factor alpha. In order to identify the receptors involved in these responses, monocytes were stimulated with purified group- or type-specific carbohydrates or lipoteichoic acid in the presence of anti-receptor monoclonal antibodies, soluble CD14, or lipopolysaccharide-binding protein. Results indicate that CD14 plays an important role in tumor necrosis factor alpha responses to all of the stimuli tested. Moreover, both CD14 and complement receptor type 3 may be involved in responses to the group-antigen.

* Corresponding author. Mailing address: Istituto di Microbiologia, Policlinico Universitario, Via Consolare Valeria, Gazzi, I-98125 Messina, Italy. Phone: 39-090-221-3310. Fax: 39-090-221-3312. E-mail: teti{at}eniware.it.

Infection and Immunity, February 2000, p. 994-998, Vol. 68, No. 2
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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