Previous Article | Next Article ![]()
Infection and Immunity, February 2000, p. 994-998, Vol. 68, No. 2
Istituto di Microbiologia, Facoltà di
Medicina e Chirurgia, Università degli Studi di Messina, I-98125
Messina,1 and Laboratorio di Micologia e
Batteriologia, Istituto Superiore di Sanità, I-00143
Rome,2 Italy, and Institute for Cancer
Research, University of Trondheim, 7489 Trondheim,
Norway3
Received 24 June 1999/Returned for modification 26 August
1999/Accepted 29 October 1999
Several group B streptococcal products have been previously found
to stimulate human monocytes to produce tumor necrosis factor alpha. In
order to identify the receptors involved in these responses, monocytes
were stimulated with purified group- or type-specific carbohydrates or
lipoteichoic acid in the presence of anti-receptor monoclonal
antibodies, soluble CD14, or lipopolysaccharide-binding protein.
Results indicate that CD14 plays an important role in tumor necrosis
factor alpha responses to all of the stimuli tested. Moreover, both
CD14 and complement receptor type 3 may be involved in responses to the
group-antigen.
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Human Monocyte Receptors Involved in Tumor Necrosis
Factor Responses to Group B Streptococcal Products
*
Corresponding author. Mailing address: Istituto di
Microbiologia, Policlinico Universitario, Via Consolare Valeria, Gazzi, I-98125 Messina, Italy. Phone: 39-090-221-3310. Fax: 39-090-221-3312. E-mail: teti{at}eniware.it.
This article has been cited by other articles:
| J. Bacteriol. | J. Virol. | Eukaryot. Cell |
|---|
| Microbiol. Mol. Biol. Rev. | Clin. Vaccine Immunol. | All ASM Journals |
|---|