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Infection and Immunity, March 2000, p. 1485-1490, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Cellular Changes and Apoptosis in the Spleens and Peripheral Blood of Mice Infected with Blood-Stage Plasmodium chabaudi chabaudi AS

Helena Helmby,* Gun Jönsson, and Marita Troye-Blomberg

Department of Immunology, Stockholm University, S-106 91 Stockholm, Sweden

Received 5 August 1999/Returned for modification 12 October 1999/Accepted 8 December 1999

Infection with blood-stage Plasmodium chabaudi chabaudi AS results in splenomegaly, peripheral leukocytosis, and a major activation of the immune system. The frequencies and absolute numbers of T-cell, B-cell, and macrophage populations in spleen and peripheral blood from P. chabaudi-infected BALB/c mice were compared and found to be significantly altered during acute infection. The kinetics of the redistribution of the different cell types in spleen and peripheral blood were different, with T and B cells appearing in the blood when their frequencies and absolute numbers in the spleen were low. The frequency and absolute number of apoptotic cells in the spleen were increased during acute P. chabaudi infection and involved both T cells, B cells, and macrophages. Both Fas and Fas-ligand expression were increased in the spleen. Taken together, our data provide new information on the complex cellular interactions that take place in the immune system during blood-stage malaria infection in a mouse model.

* Corresponding author. Present address: School of Biological Sciences, The University of Manchester, Stopford Building 3.239, Manchester M13 9PT, United Kingdom. Phone: 44-161-275-5319. Fax: 44-161-275-5640. E-mail: mqbssheh{at}man.ac.uk.

Infection and Immunity, March 2000, p. 1485-1490, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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