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Infection and Immunity, March 2000, p. 1485-1490, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Cellular Changes and Apoptosis in the Spleens and
Peripheral Blood of Mice Infected with Blood-Stage Plasmodium
chabaudi chabaudi AS
Helena
Helmby,*
Gun
Jönsson, and
Marita
Troye-Blomberg
Department of Immunology, Stockholm
University, S-106 91 Stockholm, Sweden
Received 5 August 1999/Returned for modification 12 October
1999/Accepted 8 December 1999
Infection with blood-stage Plasmodium chabaudi chabaudi
AS results in splenomegaly, peripheral leukocytosis, and a major
activation of the immune system. The frequencies and absolute numbers
of T-cell, B-cell, and macrophage populations in spleen and peripheral blood from P. chabaudi-infected BALB/c mice were compared
and found to be significantly altered during acute infection. The kinetics of the redistribution of the different cell types in spleen
and peripheral blood were different, with T and B cells appearing in
the blood when their frequencies and absolute numbers in the spleen
were low. The frequency and absolute number of apoptotic cells in the
spleen were increased during acute P. chabaudi infection and involved both T cells, B cells, and macrophages. Both Fas and
Fas-ligand expression were increased in the spleen. Taken together, our
data provide new information on the complex cellular interactions that
take place in the immune system during blood-stage malaria infection in
a mouse model.
*
Corresponding author. Present address: School of
Biological Sciences, The University of Manchester, Stopford Building
3.239, Manchester M13 9PT, United Kingdom. Phone: 44-161-275-5319. Fax: 44-161-275-5640. E-mail: mqbssheh{at}man.ac.uk.
Infection and Immunity, March 2000, p. 1485-1490, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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