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Infection and Immunity, March 2000, p. 1569-1573, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Immune Responses to Specific Antigens of Streptococcus pneumoniae and Moraxella catarrhalis in the Respiratory Tract

Takao Samukawa,1 Noboru Yamanaka,1 Susan Hollingshead,2 Karin Klingman,3 and Howard Faden3,*

Wakayama Medical College, Wakayama Japan1; University of Alabama at Birmingham, Birmingham, Alabama2; and State University of New York School of Medicine and Biomedical Sciences, Buffalo, New York3

Received 18 October 1999/Returned for modification 22 November 1999/Accepted 6 December 1999

Streptococcus pneumoniae and Moraxella catarrhalis are two common respiratory pathogens, colonizing as many as 54 and 72% of children, respectively, by 1 year of age. The immune responses to surface protein A of S. pneumoniae (PspA) and the high-molecular-weight outer membrane protein of M. catarrhalis (UspA) in the sera of various age groups in the general population and in the nasopharynges of 30 children monitored from birth through 1 year of age were evaluated. Immunoglobulin G (IgG) was the dominant serum antibody to PspA and UspA. Whereas the serum antibody response to PspA peaked in childhood, the antibody response to UspA peaked in adulthood. In the first 2 years of life, comparable amounts of IgM and IgG antibodies to both proteins were observed. In older persons, IgG antibodies to both antigens predominated over IgM antibodies. The levels of IgA antibody to these antigens in serum remained low during the first 2 years of life. The levels of IgM antibody to the two antigens in serum exceeded the levels of IgA antibody to the same two antigens throughout life. Although IgA was the dominant antibody to PspA and UspA in airway secretions, it was detected in a minority of the children (3 of 15 for PspA and 0 of 15 for UspA). Even the majority of the children previously colonized with these pathogens lacked antibody to them in their secretions.

* Corresponding author. Mailing address: Division of Infectious Diseases, Children's Hospital of Buffalo, 219 Bryant St., Buffalo, NY 14222. Phone: (716) 878-7161. Fax: (716) 888-3804. E-mail: hfaden{at}upa.chob.edu.

Infection and Immunity, March 2000, p. 1569-1573, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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