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Infection and Immunity, March 2000, p. 1692-1695, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Enhanced Susceptibility to Subcutaneous Abscess Formation and Persistent Infection around Catheters Is Associated with Sustained Interleukin-1beta Levels

J. J. Boelens,1,* S. A. J. Zaat,1 J. L. Murk,1 J. J. Weening,2 T. van der Poll,3 and J. Dankert1

Department of Medical Microbiology,1 Department of Pathology,2 and Department of Experimental Internal Medicine,3 Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands

Received 26 April 1999/Returned for modification 1 September 1999/Accepted 8 November 1999

A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1beta (IL-1beta ) production was found. Apparently, sustained levels of IL-1beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.

* Corresponding author. Mailing address: Department of Pediatrics, J6-S-208, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. Phone: 71-5262824. Fax: 71-5248198. E-mail: boelensjj{at}yahoo.com.

Infection and Immunity, March 2000, p. 1692-1695, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Broekhuizen, C. A. N., de Boer, L., Schipper, K., Jones, C. D., Quadir, S., Feldman, R. G., Dankert, J., Vandenbroucke-Grauls, C. M. J. E., Weening, J. J., Zaat, S. A. J. (2007). Peri-Implant Tissue Is an Important Niche for Staphylococcus epidermidis in Experimental Biomaterial-Associated Infection in Mice. Infect. Immun. 75: 1129-1136 [Abstract] [Full Text]  
  • Kwakman, P. H. S., te Velde, A. A., Vandenbroucke-Grauls, C. M. J. E., van Deventer, S. J. H., Zaat, S. A. J. (2006). Treatment and Prevention of Staphylococcus epidermidis Experimental Biomaterial-Associated Infection by Bactericidal Peptide 2. Antimicrob. Agents Chemother. 50: 3977-3983 [Abstract] [Full Text]  
  • Boelens, J. J., van der Poll, T., Zaat, S. A. J., Murk, J. L. A. N., Weening, J. J., Dankert, J. (2000). Interleukin-1 Receptor Type I Gene-Deficient Mice Are Less Susceptible to Staphylococcus epidermidis Biomaterial-Associated Infection than Are Wild-Type Mice. Infect. Immun. 68: 6924-6931 [Abstract] [Full Text]  


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