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Infection and Immunity, March 2000, p. 1710-1713, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Intestinal Epithelial Cell Apoptosis following Cryptosporidium parvum Infection

Declan F. McCole,1 Lars Eckmann,1 Fabrice Laurent,2 and Martin F. Kagnoff1,*

Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0623,1 and Laboratoire de Protozoologie, Centre INRA de Tours, 37380 Nouzilly, France2

Received 26 August 1999/Returned for modification 7 October 1999/Accepted 22 November 1999

Cryptosporidium parvum induces moderate levels of apoptosis of cultured human intestinal epithelial cells, which are maximal at 24 h after infection. Apoptosis is further increased in C. parvum-infected cells by inhibition of NF-kappa B. C. parvum infection also attenuates epithelial apoptosis induced by strongly proapoptotic agents. The data suggest C. parvum has developed strategies to limit apoptosis in order to facilitate its growth and maturation in the early period after epithelial cell infection.

* Corresponding author. Mailing address: Department of Medicine (0623D), University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0623. Phone: (858) 534-4622. Fax: (858) 534-5691. E-mail: mkagnoff{at}ucsd.edu.

Infection and Immunity, March 2000, p. 1710-1713, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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