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Infection and Immunity, March 2000, p. 1727-1730, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Stability of Borrelia burgdorferi bdr Loci In Vitro and In Vivo

Wolfram R. Zückert* and Alan G. Barbour

Department of Microbiology and Molecular Genetics and Department of Medicine, University of California Irvine College of Medicine, Irvine, California 92697

Received 1 October 1999/Returned for modification 23 November 1999/Accepted 8 December 1999

The Lyme disease spirochete Borrelia burgdorferi expresses diverse subsurface yet antigenically cross-reactive Bdr protein paralogs from distinct circular- and linear-plasmid loci. We assessed the possible effects of in vitro and in vivo growth on bdr locus structure, searching for recombinational events leading to either deletions or insertions of central repeat units or novel amino- and carboxy-terminus combinations. Our data indicate that, apart from plasmid loss during in vitro cultivation, the bdr paralog loci of strain B31 are stable. This suggests that recombinatorial variation of bdr genes is not essential for persistent mammalian infection.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, University of California Irvine, B240 Medical Sciences I, Irvine, CA 92697. Phone: (949) 824-3737. Fax: (949) 824-8598. E-mail: wzuecker{at}uci.edu.

Infection and Immunity, March 2000, p. 1727-1730, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Gilmore, R. D. Jr., Howison, R. R., Schmit, V. L., Nowalk, A. J., Clifton, D. R., Nolder, C., Hughes, J. L., Carroll, J. A. (2007). Temporal Expression Analysis of the Borrelia burgdorferi Paralogous Gene Family 54 Genes BBA64, BBA65, and BBA66 during Persistent Infection in Mice. Infect. Immun. 75: 2753-2764 [Abstract] [Full Text]  


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