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Infection and Immunity, March 2000, p. 1740-1745, Vol. 68, No. 3
Departamento de Microbiología,
Facultad de Medicina,1 Unidad de
Investigación, Hospital Clínico
Universitario,2 and Instituto de
Biología y Genética Molecular, Consejo Superior de
Investigaciones Cientificas,3 Valladolid, Spain
Received 28 October 1999/Returned for modification 16 November
1999/Accepted 6 December 1999
Smooth lipopolysaccharide (S-LPS) and lipid A of Brucella
abortus and Brucella melitensis induced the
production of nitric oxide (NO) by rat adherent peritoneal cells, but
they induced lower levels of production of NO than Escherichia
coli LPS. The participation of the inducible isoform of NO
synthase (iNOS) was confirmed by the finding of an increased expression
of both iNOS mRNA and iNOS protein. These observations might help to
explain (i) the acute outcome of Brucella infection in
rodents, (ii) the low frequency of septic shock in human brucellosis,
and (iii) the prolonged intracellular survival of Brucella
in humans.
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Lipopolysaccharides of Brucella abortus
and Brucella melitensis Induce Nitric Oxide Synthesis in Rat
Peritoneal Macrophages
*
Corresponding author. Mailing address: IBGM, Facultad
de Medicina, 47005-Valladolid, Spain. Phone: 34-983-423273. Fax:
34-983-423588. E-mail: mscres{at}ibgm.uva.es.
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