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Infection and Immunity, March 2000, p. 1746-1751, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Polymorphonuclear Neutrophils Are Necessary for the Recruitment of CD8+ T Cells in the Liver in a Pregnant Mouse Model of Chlamydophila abortus (Chlamydia psittaci Serotype 1) Infection

Roberto Montes de Oca,1,2 Antonio J. Buendía,3 Laura Del Río,3 Joaquín Sánchez,1 Jesús Salinas,3,* and Jose A. Navarro1

Departamento de Histología y Anatomía Patológica1 and Departamento de Patología Animal (Microbiología e Inmunología),3 Facultad de Veterinaria, Universidad de Murcia, Murcia, Spain, and Departamento de Salud Animal, Facultad de Veterinaria, Universidad Autónoma de Estado de México, Toluca, México2

Received 9 July 1999/Returned for modification 7 September 1999/Accepted 23 November 1999

The role of polymorphonuclear neutrophils (PMNs) in the development of the specific immune response against Chlamydophila abortus (Chlamydia psittaci serotype 1) infection was studied in a pregnant mouse model involving treatment with RB6-8C5 monoclonal antibody. PMN depletion significantly affected the immune response in the liver, in which the T-lymphocyte and F4/80+ cell populations decreased, particularly the CD8+ T-cell population. A Th1-like response, characterized by high levels of gamma interferon without detectable levels of interleukin 4 (IL-4) in serum, was observed in both depleted and nondepleted mice, although an increased production of IL-10 was detected in the depleted group. Our results suggest that PMNs play a very important role in the recruitment of other leukocyte populations to the inflammatory foci but have little influence in the polarization of the immune specific response toward a Th1-like response.

* Corresponding author. Mailing address: Departamento de Patología Animal (Microbiología e Inmunología), Facultad de Veterinaria, Universidad de Murcia, Campus de Espinardo, Murcia 30100, Spain. Phone: (34) 968 364729. Fax: (34) 968 364147. E-mail: jsalinas{at}fcu.um.es.

Infection and Immunity, March 2000, p. 1746-1751, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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