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Infection and Immunity, April 2000, p. 2187-2195, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Antibody-Mediated Elimination of the Obligate Intracellular Bacterial Pathogen Ehrlichia chaffeensis during Active Infection

Gary M. Winslow,1,2,* Eric Yager,2 Konstantin Shilo,1,dagger Erin Volk,2 Andrew Reilly,1 and Frederick K. Chu1

Wadsworth Center, New York State Department of Health, Albany, New York 12201-2002,1 and Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York 12201-05092

Received 21 May 1999/Returned for modification 14 October 1999/Accepted 3 January 2000

It is generally accepted that cellular, but not humoral immunity, plays an important role in host defense against intracellular bacteria. However, studies of some of these pathogens have provided evidence that antibodies can provide immunity if present during the initiation of infection. Here, we examined immunity against infection by Ehrlichia chaffeensis, an obligate intracellular bacterium that causes human monocytic ehrlichiosis. Studies with mice have demonstrated that immunocompetent strains are resistant to persistent infection but that SCID mice become persistently and fatally infected. Transfer of immune serum or antibodies obtained from immunocompetent C57BL/6 mice to C57BL/6 scid mice provided significant although transient protection from infection. Bacterial clearance was observed when administration occurred at the time of inoculation or well after infection was established. The effect was dose dependent, occurred within 2 days, and persisted for as long as 2 weeks. Weekly serum administration prolonged the survival of susceptible mice. Although cellular immunity is required for complete bacterial clearance, the data show that antibodies can play a significant role in the elimination of this obligate intracellular bacterium during active infection and thus challenge the paradigm that humoral responses are unimportant for immunity to such organisms.

* Corresponding author. Mailing address: Wadsworth Center, 120 New Scotland Ave., Albany, NY 12208. Phone: (518) 473-2795. Fax: (518) 486-4395. E-mail: gary.winslow{at}wadsworth.org.

dagger Present address: Department of Pathology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109.

Infection and Immunity, April 2000, p. 2187-2195, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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