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Infection and Immunity, April 2000, p. 2231-2236, Vol. 68, No. 4
Pediatrics1 and
Biology3 Departments, Georgetown
University, Washington, D.C.; Biotechnology Center, University
of Yaounde I, Yaounde, Cameroon2;
Malaria Vaccine Development Unit, National Institute of Allergy
and Infectious Diseases, National Institutes of Health, Bethesda,
Maryland4; and The Queensland Institute
of Medical Research and The University of Queensland, Brisbane,
Australia5
Received 22 September 1999/Returned for modification 1 November
1999/Accepted 10 January 2000
The Plasmodium falciparum rhoptry-associated proteins 1 and 2 (RAP1 and RAP2) are candidate antigens for a subunit malaria vaccine. The design of the study, which looks at the acquisition of
immunity to malaria from childhood to old age, has allowed us to
document the interaction of HLA and age on levels of antibody to
specific malarial antigens. Antibodies reach maximum levels to RAP1
after the age of 15 but to RAP2 only after the age of 30. The effect of
HLA-DRB1 and -DQB1 and age on levels of antibody to rRAP1 and rRAP2 was
analyzed with a multiple regression model in which all HLA alleles and
age were independent variables. DQB1*0301 and -*03032 showed an
age-dependent association with levels of antibody to rRAP1, being
significant in children 5 to 15 years (P < 0.001) but
not in individuals over 15 years of age. DRB1*03011 showed an
age-dependent association with antibody levels to rRAP2; however, this
association was in adults over the age of 30 years (P < 0.01) but not in individuals under the age of 30 years. No associations were detected between DRB1 alleles and RAP1 antibody levels or between DQB1 alleles and RAP2 antibody levels. Thus, not only
the HLA allele but also the age at which an interaction is manifested
varies for different malarial antigens. The interaction may influence
either the rate of acquisition of antibody or the final level of
antibody acquired by adults.
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Interaction of HLA and Age on Levels of Antibody to
Plasmodium falciparum Rhoptry-Associated Proteins 1 and 2
*
Corresponding author. Mailing address: Georgetown
University Medical School, PCS Bldg.-LD8D, 3900 Reservoir Rd., NW,
Washington, D.C. 20007. Phone: (202) 687-1529. Fax: (202) 687-7161. E-mail: johnsoa2{at}gunet.georgetown.edu.
Infection and Immunity, April 2000, p. 2231-2236, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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