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Infection and Immunity, April 2000, p. 2333-2337, Vol. 68, No. 4
0019-9567/00/$04.00+0

Specificity of Human Antibodies Reactive with Pneumococcal C Polysaccharide

Carl E. Frasch* and Nelydia F. Concepcion

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Bethesda, Maryland

Received 8 July 1999/Returned for modification 28 October 1999/Accepted 21 December 1999

Antibodies reactive with C polysaccharide (PS) were found in healthy adults, pneumococcal patients, and vaccinees. These antibodies were not directed to the phosphocholine determinant of the C PS, as they appear to be in mice, since the human antibodies were inhibitable only with C PS. We found another population of phosphocholine-specific antibodies inhibitable only by phosphocholine and related compounds.

* Corresponding author. Mailing address: Division of Bacterial Products, CBER, 1401 Rockville Pike, HFM-428, Rockville, MD 20852. Phone: (301) 496-1920. Fax: (301) 402-2776. E-mail: frasch{at}cber.fda.gov.

Infection and Immunity, April 2000, p. 2333-2337, Vol. 68, No. 4
0019-9567/00/$04.00+0


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