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Infection and Immunity, April 2000, p. 2363-2365, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Disparate Requirement for T Cells in Resistance to Mucosal and Acute Systemic Candidiasis

Jessica Jones-Carson,1 Andres Vazquez-Torres,1 Thomas Warner,2 and Edward Balish3,4,*

Division of Infectious Diseases, University of Colorado Health Science Center, Denver, Colorado,1 and Departments of Surgical Pathology,2 Surgery,3 and Medical Microbiology and Immunology,4 University of Wisconsin Medical School, Madison, Wisconsin

Received 6 July 1999/Returned for modification 23 August 1999/Accepted 3 January 2000

Although highly susceptible to orogastric candidiasis, T-cell receptor delta - and alpha -chain knockout mice, deficient in gamma delta and alpha beta T cells, respectively, were found to be resistant to disseminated candidiasis of endogenous origin and to acute systemic candidiasis (resulting from intravenous injection).

* Corresponding author. Mailing address: University of Wisconsin Medical School, Departments of Surgery and Medical Microbiology/Immunology, 1300 University Ave., 4638 MSC, Madison, WI 53706-1532. Phone: (608) 263-1670. Fax: (608) 265-3461. E-mail: balish{at}surgery.wisc.edu.

Infection and Immunity, April 2000, p. 2363-2365, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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