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Infection and Immunity, April 2000, p. 2369-2373, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Molecular and Immunological Analyses of the Borrelia turicatae Bdr Protein Family

Jason A. Carlyon,^1, David M. Roberts,¹ Michael Theisen,² Christina Sadler,³ and Richard T. Marconi^1,*

Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298¹; Department of Biology, Mary Baldwin College, Staunton, Virginia 24401³; and Staten Serum Institute, Copenhagen, Denmark²

Received 17 November 1999/Returned for modification 15 December 1999/Accepted 3 January 2000

Here, we describe the molecular and immunological characterization of the bdr gene family of Borrelia turicatae, a relapsing-fever spirochete. Nine bdr alleles belonging to two different subfamilies were sequenced and localized to linear plasmids. Anti-Bdr antiserum was generated and used to analyze Bdr expression in pre- and postinfection isogenic populations. The analyses presented here provide a detailed characterization of the Bdr proteins in a relapsing-fever spirochete species, enhancing our understanding of these proteins at the genus-wide level.

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^* Corresponding author. Mailing address: Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298. Phone: (804) 828-3779. Fax: (804) 828-9946. E-mail: RMARCONI{at}hsc.vcu.edu.

Present address: Department of Internal Medicine, Section of Rheumatology, Laboratory of Clinical Investigation 604, Yale University, New Haven, CT 06520-8031.

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Infection and Immunity, April 2000, p. 2369-2373, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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