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Infection and Immunity, April 2000, p. 2369-2373, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Molecular and Immunological Analyses of the Borrelia turicatae Bdr Protein Family

Jason A. Carlyon,1,dagger David M. Roberts,1 Michael Theisen,2 Christina Sadler,3 and Richard T. Marconi1,*

Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 232981; Department of Biology, Mary Baldwin College, Staunton, Virginia 244013; and Staten Serum Institute, Copenhagen, Denmark2

Received 17 November 1999/Returned for modification 15 December 1999/Accepted 3 January 2000

Here, we describe the molecular and immunological characterization of the bdr gene family of Borrelia turicatae, a relapsing-fever spirochete. Nine bdr alleles belonging to two different subfamilies were sequenced and localized to linear plasmids. Anti-Bdr antiserum was generated and used to analyze Bdr expression in pre- and postinfection isogenic populations. The analyses presented here provide a detailed characterization of the Bdr proteins in a relapsing-fever spirochete species, enhancing our understanding of these proteins at the genus-wide level.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298. Phone: (804) 828-3779. Fax: (804) 828-9946. E-mail: RMARCONI{at}hsc.vcu.edu.

dagger Present address: Department of Internal Medicine, Section of Rheumatology, Laboratory of Clinical Investigation 604, Yale University, New Haven, CT 06520-8031.

Infection and Immunity, April 2000, p. 2369-2373, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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