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Infection and Immunity, April 2000, p. 2386-2389, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Induction of Emetic, Pyrexic, and Behavioral Effects of Staphylococcus aureus Enterotoxin B in the Ferret

Angela Wright,1 Paul L. R. Andrews,2 and Richard W. Titball1,*

Defence Evaluation and Research Agency, CBD Porton Down, Salisbury, Wiltshire SP4 OJQ,1 and Department of Physiology, St. George's Hospital Medical School, London SW17 0RE,2 United Kingdom

Received 15 November 1999/Returned for modification 14 December 1999/Accepted 3 January 2000

Ferrets which had been orally dosed with 5 mg of Staphylococcal enterotoxin B (SEB) responded with an increase in subcutaneous temperature. At 75 min, the subcutaneous temperature was significantly higher (+ 0.9°C ± 0.38°C, P < 0.007) than in control animals. Animals dosed with 1 or 2 mg of SEB responded with a small, but not significant, increase in subcutaneous temperature. All of the animals dosed with 5 mg of SEB retched and vomited. The mean latency for the onset of retching was 105 ± 36 min, and the mean latency for the onset of vomiting was 106 ± 34 min. The mean number of retches was 17.8 ± 19.6, and the mean number of vomits was 2.0 ± 1.5. These findings indicate that ferrets can be used as alternatives to primates for the study of the biological activities of SEB.

* Corresponding author. Mailing address: Defence Evaluation and Research Agency, CBD Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom. Phone: 44 (0)1980 613301. Fax: 44 (0)1980 613284. E-mail: RTITBALL{at}dera.gov.uk.

Infection and Immunity, April 2000, p. 2386-2389, Vol. 68, No. 4
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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  • Hu, D.-L., Omoe, K., Shimoda, Y., Nakane, A., Shinagawa, K. (2003). Induction of Emetic Response to Staphylococcal Enterotoxins in the House Musk Shrew (Suncus murinus). Infect. Immun. 71: 567-570 [Abstract] [Full Text]  


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