Cytophilic Immunoglobulin Responses to Plasmodium falciparum Glutamate-Rich Protein Are Correlated with Protection against Clinical Malaria in Dielmo, Senegal

doi:10.1128/IAI.68.5.2617-2620.2000

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Infection and Immunity, May 2000, p. 2617-2620, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Cytophilic Immunoglobulin Responses to Plasmodium falciparum Glutamate-Rich Protein Are Correlated with Protection against Clinical Malaria in Dielmo, Senegal

Claude Oeuvray,¹ Michael Theisen,² Christophe Rogier,³ Jean-Francois Trape,⁴ Søren Jepsen,² and Pierre Druilhe¹^,^*

Laboratoire de Parasitologie BioMedicale, Institut Pasteur, Paris, France;¹ Department of Clinical Biochemistry, Statens Seruminstitut, Copenhagen, Denmark;² and Institut Pasteur de Dakar³ and Laboratoire de Paludologie, Institut de Recherche pour le Développement,⁴ Dakar, Sénégal

Received 15 November 1999/Returned for modification 24 January 2000/Accepted 9 February 2000

The goal of this study was to analyze antibody responses to Plasmodium falciparum glutamate-rich protein (GLURP) using clinicaldata and plasma samples obtained from villagers of Dielmo, Senegal.This molecule was chosen because it is targeted by human antibodieswhich induce parasite growth inhibition in antibody-dependentcellular inhibition (ADCI) assays. The results showed a strongcorrelation between protection against malaria attacks and levelsof immunoglobulin G2 (IgG2) and IgG3 against GLURP_94-489(R0) and IgG3 against GLURP_705-1178 (R2) when correctedfor the confounding effect of age-related exposure to malaria.Thus, GLURP may play a role in the induction of protective immunityagainst P. falciparummalaria.

^* Corresponding author. Mailing address: Laboratoire de Parasitologie Bio-Médicale, Institut Pasteur, 28 rue du Dr. Roux, 75015Paris, France. Phone: (33) 145688578. Fax: (33) 145688640. E-mail:druilhe{at}pasteur.fr.

Infection and Immunity, May 2000, p. 2617-2620, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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