Immunization with Parasite-Derived Apical Membrane Antigen 1 or Passive Immunization with a Specific Monoclonal Antibody Protects BALB/c Mice against Lethal Plasmodium yoelii yoelii YM Blood-Stage Infection

doi:10.1128/IAI.68.5.2899-2906.2000

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Infection and Immunity, May 2000, p. 2899-2906, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Immunization with Parasite-Derived Apical Membrane Antigen 1 or Passive Immunization with a Specific Monoclonal Antibody Protects BALB/c Mice against Lethal Plasmodium yoelii yoelii YM Blood-Stage Infection

David L. Narum,¹^,^* Solabomi A. Ogun,¹ Alan W. Thomas,² and Anthony A. Holder¹

Division of Parasitology, National Institute for Medical Research, London, NW7 1AA, United Kingdom,¹ and Department of Parasitology, Biomedical Primate Research Centre, 2288GJ Rijswijk, The Netherlands²

Received 4 November 1999/Returned for modification 13 December 1999/Accepted 27 January 2000

We have purified apical merozoite antigen 1 (AMA-1) from extracts of red blood cells infected with the rodent malaria parasitePlasmodium yoelii yoelii YM. When used to immunize mice, the proteininduced a strong protective response against a challenge withthe parasite. Monoclonal antibodies specific for P. yoelii yoeliiAMA-1 were prepared, and one was very effective against the parasiteon passive immunization. A second protein that appears to be locatedin the apical rhoptry organelles and associated with AMA-1 wasidentified.

^* Corresponding author. Present address: EntreMed, Inc., 9640 Medical Center Dr., Rockville, MD 20850. Phone: (301) 517-3307.Fax: (301) 217-9594. E-mail: davidn{at}entremed.com.

Infection and Immunity, May 2000, p. 2899-2906, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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