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Infection and Immunity, May 2000, p. 2899-2906, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Immunization with Parasite-Derived Apical Membrane Antigen 1 or Passive Immunization with a Specific Monoclonal Antibody Protects BALB/c Mice against Lethal Plasmodium yoelii yoelii YM Blood-Stage Infection

David L. Narum,1,* Solabomi A. Ogun,1 Alan W. Thomas,2 and Anthony A. Holder1

Division of Parasitology, National Institute for Medical Research, London, NW7 1AA, United Kingdom,1 and Department of Parasitology, Biomedical Primate Research Centre, 2288GJ Rijswijk, The Netherlands2

Received 4 November 1999/Returned for modification 13 December 1999/Accepted 27 January 2000

We have purified apical merozoite antigen 1 (AMA-1) from extracts of red blood cells infected with the rodent malaria parasite Plasmodium yoelii yoelii YM. When used to immunize mice, the protein induced a strong protective response against a challenge with the parasite. Monoclonal antibodies specific for P. yoelii yoelii AMA-1 were prepared, and one was very effective against the parasite on passive immunization. A second protein that appears to be located in the apical rhoptry organelles and associated with AMA-1 was identified.

* Corresponding author. Present address: EntreMed, Inc., 9640 Medical Center Dr., Rockville, MD 20850. Phone: (301) 517-3307. Fax: (301) 217-9594. E-mail: davidn{at}entremed.com.

Infection and Immunity, May 2000, p. 2899-2906, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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