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Infection and Immunity, May 2000, p. 2976-2978, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Role of Eosinophils in the Pathogenesis of Mycobacterium bovis BCG Infection in Gamma Interferon Receptor-Deficient Mice

Joanna Kirman,1,dagger Zamsyari Zakaria,1 Kathy McCoy,1,Dagger Brett Delahunt,2 and Graham Le Gros1,*

Malaghan Institute of Medical Research1 and Department of Pathology, Wellington School of Medicine,2 Wellington South, New Zealand

Received 18 October 1999/Returned for modification 13 December 1999/Accepted 7 January 2000

A profound eosinophil infiltration of granulomas is observed in the lungs of Mycobacterium bovis bacillus Calmette Guérin-infected gamma interferon receptor-deficient mice. Blockade of eosinophil proliferation and recruitment into the lung by treatment with anti-interleukin-5 monoclonal antibody marginally reduced mycobacterial growth within the lung but did not affect dissemination of the infection to other tissues.

* Corresponding author. Mailing address: Malaghan Institute of Medical Research, P.O. Box 7060, Wellington South, New Zealand. Phone: 64-4-389-5096. Fax: 64-4-389-5095. E-mail: glegros{at}malaghan.org.nz.

dagger Present address: Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892.

Dagger Present address: Institute of Experimental Immunology, University Hospital Zürich, 8091 Zürich, Switzerland.

Infection and Immunity, May 2000, p. 2976-2978, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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