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Infection and Immunity, May 2000, p. 2985-2991, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Interaction of Salmonella enterica Serotype Typhimurium with Dendritic Cells Is Defined by Targeting to Compartments Lacking Lysosomal Membrane Glycoproteins

Francisco García-Del Portillo,1,* Heidrun Jungnitz,2 Manfred Rohde,2 and Carlos A. Guzmán2

Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid---CSIC, Cantoblanco, 28049 Madrid, Spain,1 and GBF-National Research Centre for Biotechnology, 38124 Braunschweig, Germany2

Received 2 December 1999/Returned for modification 29 December 1999/Accepted 18 January 2000

Dendritic cells (DCs) play a central role in the generation of acquired immunity to infections by pathogenic microorganisms. Salmonella enterica serotype Typhimurium is known to survive and proliferate intracellularly within macrophages and nonphagocytic cells, but no data exist on how this pathogen interacts with DCs. In this report, we show the capacity of serotype Typhimurium to survive within the established mouse DC line CB1. In contrast to the case for the macrophage model, the compartments of DCs containing serotype Typhimurium are devoid of lysosomal membrane glycoproteins and the PhoPQ two-component regulatory system is not essential for pathogen intracellular survival.

* Corresponding author. Mailing address: Centro de Biología Molecular "Severo Ochoa," Universidad Autónoma de Madrid-CSIC, Cantoblanco, 28049-Madrid, Spain. Phone: 34-91-397-8099. Fax: 34-91-397-8087. E-mail: fgportillo{at}cbm.uam.es.

Infection and Immunity, May 2000, p. 2985-2991, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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