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Infection and Immunity, May 2000, p. 2992-2994, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Bactericidal/Permeability-Increasing Protein Prevents Mucosal Damage in an Experimental Rat Model of Chronic Otitis Media with Effusion

Marja J. Nell,1,* Henk K. Koerten,2 and Jan J. Grote1

Department of Otorhinolaryngology1 and Center for Electronmicroscopy,2 Leiden University Medical Center, Leiden, The Netherlands

Received 7 September 1999/Returned for modification 15 November 1999/Accepted 27 January 2000

In this study, the efficacy of bactericidal/permeability-increasing protein (BPI) was assessed in a rat model of chronic otitis media with effusion. BPI injection prevented disturbance of the mucociliary clearance system of the middle ear. Hence, it is postulated that BPI can be a new therapy for chronic otitis media with effusion.

* Corresponding author. Mailing address: Dept. of Otorhinolaryngology (Room J2-60), Leiden University Medical Center, P.O. Box 9600, NL-2300 RC, Leiden, The Netherlands. Phone: 031 71 526 2439. Fax: 031 71 524 8201. E-mail: M.J.Nell{at}lumc.nl.

Infection and Immunity, May 2000, p. 2992-2994, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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