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Infection and Immunity, May 2000, p. 3002-3006, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Depressed CD40 Ligand Expression Contributes to Reduced Gamma Interferon Production in Human Tuberculosis

Buka Samten,1 Elaine K. Thomas,2 Jianhua Gong,1 and Peter F. Barnes1,3,4,*

Center for Pulmonary and Infectious Disease Control1 and Departments of Cell Biology3 and Medicine,4 University of Texas Health Center, Tyler, Texas 75710, and Immunex Corporation, Seattle, Washington 981012

Received 22 September 1999/Returned for modification 11 November 1999/Accepted 14 February 2000

Expression of CD40 ligand (CD40L) correlated directly with Mycobacterium tuberculosis-stimulated gamma interferon (IFN-gamma ) production by peripheral blood mononuclear cells (PBMC) from tuberculosis patients and healthy tuberculin reactors. The CD40L agonist increased M. tuberculosis-induced IFN-gamma production by PBMC, and anti-CD40 or anti-CD40L antibodies reduced IFN-gamma production. CD40L expression on PBMC was reduced by exposure to B cells and to soluble factors from M. tuberculosis-infected monocytes. These findings suggest that CD40L dysregulation contributes to reduced IFN-gamma production in human tuberculosis.

* Corresponding author. Center for Pulmonary and Infectious Disease Control, The University of Texas Health Center at Tyler, 11937 U.S. Highway 271, Tyler, TX 75708-3154. Phone: (903) 877-7790. Fax: (903) 877-7989. E-mail: pbarnes{at}uthct.edu.

Infection and Immunity, May 2000, p. 3002-3006, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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