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Infection and Immunity, May 2000, p. 3007-3009, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Characterization of Ferrochelatase (hemH) Mutations in Haemophilus influenzae

Stefan Schlör,1 Mark Herbert,2 Michaela Rodenburg,1 Julia Blass,1 and Joachim Reidl1,*

Zentrum für Infektionsforschung, Universität Würzburg, 97070 Würzburg, Germany,1 and Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom2

Received 7 October 1999/Returned for modification 22 November 1999/Accepted 11 January 2000

Haemophilus influenzae lacks most of the biosynthetic enzymes for hemin synthesis. However, the organism has retained ferrochelatase activity, which we identified to be encoded by a hemH-homologous gene. In this report we characterize the growth physiology conferred by hemH mutations under infection and laboratory conditions.

* Corresponding author. Mailing address: Zentrum für Infektionsforschung, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany. Phone: (49) 931 312153. Fax: (49) 931 312578. E-mail: joachim.reidl{at}mail.uni-wuerzburg.de.

Infection and Immunity, May 2000, p. 3007-3009, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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