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Infection and Immunity, May 2000, p. 3019-3022, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Immunoglobulin G3 Antibodies Specific for the 19-Kilodalton Carboxyl-Terminal Fragment of Plasmodium yoelii Merozoite Surface Protein 1 Transfer Protection to Mice Deficient in Fc-gamma RI Receptors

Peter Vukovic,1 P. Mark Hogarth,2 Nadine Barnes,2 David C. Kaslow,3,dagger and Michael F. Good1,*

The Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research and the Australian Centre for International and Tropical Health and Nutrition, The University of Queensland, Brisbane 4029,1 and The Austin Research Institute, Heidelberg 3084,2 Australia, and The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208923

Received 25 October 1999/Returned for modification 6 December 1999/Accepted 21 February 2000

Merozoite surface protein 1 (MSP-119) is a leading malaria vaccine candidate. Specific antibodies contribute to immunity; binding to macrophages is believed to represent the main action of malaria antibodies. We show that an MSP-119-specific immunoglobulin G3 (IgG3) monoclonal antibody can passively transfer protection to mice deficient in the alpha  chain of Fc-gamma RI whose macrophages cannot bind IgG3.

* Corresponding author. Mailing address: The Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, QLD 4029, Australia. Phone: 61 7 33620404. Fax: 61 7 33620104. E-mail: michaelG{at}qimr.edu.au.

dagger Present address: Virus and Cell Biology, Merck Research Laboratories, West Point, PA 19486.

Infection and Immunity, May 2000, p. 3019-3022, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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