Infection and Immunity, May 2000, p. 3019-3022, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
RI Receptors
andThe Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research and the Australian Centre for International and Tropical Health and Nutrition, The University of Queensland, Brisbane 4029,1 and The Austin Research Institute, Heidelberg 3084,2 Australia, and The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208923
Received 25 October 1999/Returned for modification 6 December 1999/Accepted 21 February 2000
Merozoite surface protein 1 (MSP-119) is a leading
malaria vaccine candidate. Specific antibodies contribute to immunity; binding to macrophages is believed to represent the main action of
malaria antibodies. We show that an MSP-119-specific
immunoglobulin G3 (IgG3) monoclonal antibody can passively transfer
protection to mice deficient in the
chain of Fc-
RI whose
macrophages cannot bind IgG3.
Present address: Virus and Cell Biology, Merck Research
Laboratories, West Point, PA 19486.
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