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Infection and Immunity, May 2000, p. 3034-3035, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Role of Gamma Interferon and Interleukin-4 in Host Defense against the Human Filarial Parasite Brugia malayi

Subash Babu,1 Lisa M. Ganley,1 Thomas R. Klei,2 Leonard D. Shultz,3 and T. V. Rajan1,*

Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030-31051; Department of Veterinary Microbiology and Parasitology, Louisiana State University, Baton Rouge, Louisiana 70803-84162; and The Jackson Laboratory, Bar Harbor, Maine 046093

Received 18 November 1999/Returned for modification 4 January 2000/Accepted 11 February 2000

We have investigated the roles of gamma interferon (IFN-gamma ) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-gamma or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection.

* Corresponding author. Mailing address: Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030-3105. Phone: (860) 679-3221. Fax: (860) 679-2936. E-mail: rajan{at}neuron.uchc.edu.

Infection and Immunity, May 2000, p. 3034-3035, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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