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Infection and Immunity, May 2000, p. 3034-3035, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Role of Gamma Interferon and Interleukin-4 in Host
Defense against the Human Filarial Parasite Brugia
malayi
Subash
Babu,1
Lisa M.
Ganley,1
Thomas R.
Klei,2
Leonard D.
Shultz,3 and
T.
V.
Rajan1,*
Department of Pathology, University of
Connecticut Health Center, Farmington, Connecticut
06030-31051; Department of Veterinary
Microbiology and Parasitology, Louisiana State University, Baton Rouge,
Louisiana 70803-84162; and The Jackson
Laboratory, Bar Harbor, Maine 046093
Received 18 November 1999/Returned for modification 4 January
2000/Accepted 11 February 2000
We have investigated the roles of gamma interferon (IFN-
) and
interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-
or IL-4 prolongs the
time required to achieve sterile immunity, suggesting that both
canonical type 1 and type 2 responses are involved in the clearance of infection.
*
Corresponding author. Mailing address: Department of
Pathology, University of Connecticut Health Center, Farmington, CT
06030-3105. Phone: (860) 679-3221. Fax: (860) 679-2936. E-mail:
rajan{at}neuron.uchc.edu.
Infection and Immunity, May 2000, p. 3034-3035, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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