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Infection and Immunity, May 2000, p. 3036-3039, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The Metalloproteinase Inhibitor GI5402 Inhibits Endotoxin-Induced Soluble CD27 and CD16 Release in Healthy Humans

Pascale E. P. Dekkers,1,* Tessa ten Hove,1 Fanny N. Lauw,1 Harry R. Koene,2 Philip Lumley,3 Sander J. H. van Deventer,1 and Tom van der Poll1

Laboratory of Experimental Internal Medicine, Academic Medical Center,1 and Laboratory of Experimental and Clinical Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service,2 University of Amsterdam, Amsterdam, The Netherlands, and Department of Clinical Pharmacology, Glaxo Wellcome, Greenford, United Kingdom3

Received 5 January 2000/Accepted 2 February 2000

Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans.

* Corresponding author. Mailing address: Laboratory of Experimental Internal Medicine, Rm. G2-105, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31-20-5666034. Fax: 31-20-6977192. E-mail: P.E.Dekkers{at}AMC.UVA.NL.

Infection and Immunity, May 2000, p. 3036-3039, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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