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Infection and Immunity, May 2000, p. 3061-3063, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Increased Levels of Soluble Fas Ligand in Serum in Plasmodium falciparum Malaria

Peter Kern,1,* Manfred Dietrich,2 Christoph Hemmer,2 and Nele Wellinghausen1

Section of Infectious Diseases and Clinical Immunology, University of Ulm, Ulm,1 and Clinical Department, Bernhard Nocht Institute for Tropical Medicine, Hamburg,2 Germany

Received 20 December 1999/Returned for modification 1 February 2000/Accepted 19 February 2000

Levels of soluble Fas ligand (sFasL) in serum were elevated in patients with Plasmodium falciparum malaria and showed a significant decline during disease course. sFasL levels that were elevated before antimalarial treatment began correlated significantly with depressed total lymphocyte and T-cell counts. These data suggest that Fas-induced apoptosis might play a role in malaria-associated lymphopenia.

* Corresponding author. Mailing address: Section of Infectious Diseases and Clinical Immunology, University of Ulm, Robert-Koch-Str. 8, D-89081 Ulm, Germany. Phone: 49 731 502 4420. Fax: 49 731 502 4422. E-mail: peter.kern{at}medizin.uni-ulm.de.

Infection and Immunity, May 2000, p. 3061-3063, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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