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Infection and Immunity, June 2000, p. 3344-3348, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Antibody Is Required for Protection against Virulent but Not Attenuated Salmonella enterica Serovar Typhimurium

Stephen J. McSorley* and Marc K. Jenkins

Department of Microbiology and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Received 3 January 2000/Returned for modification 19 February 2000/Accepted 9 March 2000

Resolution of infection with attenuated Salmonella is an active process that requires CD4+ T cells. Here, we demonstrate that costimulation via the surface molecule CD28, but not antibody production by B cells, is required for clearance of attenuated aroA Salmonella enterica serovar typhimurium. In contrast, specific antibody is critical for vaccine-induced protection against virulent bacteria. Therefore, CD28+ CD4+ T cells are sufficient for clearance of avirulent Salmonella in naive hosts, whereas CD4+ T cells and specific antibodies are required for protection from virulent Salmonella in immune hosts.

* Corresponding author. Mailing address: University of Minnesota Medical School, Department of Microbiology and Center for Immunology, Room 6-220, BSBE Bldg., 312 Church St. SE, Minneapolis, MN 55455. Phone: (612) 626-1188. Fax: (612) 625-2199. E-mail: mcsor001{at}tc.umn.edu.

Infection and Immunity, June 2000, p. 3344-3348, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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