Previous Article | Next Article ![]()
Infection and Immunity, June 2000, p. 3344-3348, Vol. 68, No. 6
Department of Microbiology and Center for
Immunology, University of Minnesota Medical School, Minneapolis,
Minnesota 55455
Received 3 January 2000/Returned for modification 19 February
2000/Accepted 9 March 2000
Resolution of infection with attenuated Salmonella is
an active process that requires CD4+ T cells. Here, we
demonstrate that costimulation via the surface molecule CD28, but not
antibody production by B cells, is required for clearance of attenuated
aroA Salmonella enterica serovar typhimurium. In contrast, specific antibody is critical for vaccine-induced protection against virulent bacteria. Therefore, CD28+
CD4+ T cells are sufficient for clearance of avirulent
Salmonella in naive hosts, whereas CD4+ T cells
and specific antibodies are required for protection from virulent
Salmonella in immune hosts.
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Antibody Is Required for Protection against
Virulent but Not Attenuated Salmonella enterica
Serovar Typhimurium
*
Corresponding author. Mailing address: University of
Minnesota Medical School, Department of Microbiology and Center for
Immunology, Room 6-220, BSBE Bldg., 312 Church St. SE, Minneapolis, MN
55455. Phone: (612) 626-1188. Fax: (612) 625-2199. E-mail:
mcsor001{at}tc.umn.edu.
This article has been cited by other articles:
| J. Bacteriol. | J. Virol. | Eukaryot. Cell |
|---|
| Microbiol. Mol. Biol. Rev. | Clin. Vaccine Immunol. | All ASM Journals |
|---|