Previous Article | Next Article 
Infection and Immunity, June 2000, p. 3344-3348, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Antibody Is Required for Protection against
Virulent but Not Attenuated Salmonella enterica
Serovar Typhimurium
Stephen J.
McSorley* and
Marc K.
Jenkins
Department of Microbiology and Center for
Immunology, University of Minnesota Medical School, Minneapolis,
Minnesota 55455
Received 3 January 2000/Returned for modification 19 February
2000/Accepted 9 March 2000
Resolution of infection with attenuated Salmonella is
an active process that requires CD4+ T cells. Here, we
demonstrate that costimulation via the surface molecule CD28, but not
antibody production by B cells, is required for clearance of attenuated
aroA Salmonella enterica serovar typhimurium. In contrast, specific antibody is critical for vaccine-induced protection against virulent bacteria. Therefore, CD28+
CD4+ T cells are sufficient for clearance of avirulent
Salmonella in naive hosts, whereas CD4+ T cells
and specific antibodies are required for protection from virulent
Salmonella in immune hosts.
*
Corresponding author. Mailing address: University of
Minnesota Medical School, Department of Microbiology and Center for
Immunology, Room 6-220, BSBE Bldg., 312 Church St. SE, Minneapolis, MN
55455. Phone: (612) 626-1188. Fax: (612) 625-2199. E-mail:
mcsor001{at}tc.umn.edu.
Infection and Immunity, June 2000, p. 3344-3348, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
This article has been cited by other articles:
-
Voedisch, S., Koenecke, C., David, S., Herbrand, H., Forster, R., Rhen, M., Pabst, O.
(2009). Mesenteric Lymph Nodes Confine Dendritic Cell-Mediated Dissemination of Salmonella enterica Serovar Typhimurium and Limit Systemic Disease in Mice. Infect. Immun.
77: 3170-3180
[Abstract]
[Full Text]
-
Griffin, A., Baraho-Hassan, D., McSorley, S. J.
(2009). Successful Treatment of Bacterial Infection Hinders Development of Acquired Immunity. J. Immunol.
183: 1263-1270
[Abstract]
[Full Text]
-
Heithoff, D. M., Enioutina, E. Y., Bareyan, D., Daynes, R. A., Mahan, M. J.
(2008). Conditions That Diminish Myeloid-Derived Suppressor Cell Activities Stimulate Cross-Protective Immunity. Infect. Immun.
76: 5191-5199
[Abstract]
[Full Text]
-
Rawool, D. B., Bitsaktsis, C., Li, Y., Gosselin, D. R., Lin, Y., Kurkure, N. V., Metzger, D. W., Gosselin, E. J.
(2008). Utilization of Fc Receptors as a Mucosal Vaccine Strategy against an Intracellular Bacterium, Francisella tularensis. J. Immunol.
180: 5548-5557
[Abstract]
[Full Text]
-
Gaspal, F., Bekiaris, V., Kim, M.-Y., Withers, D. R., Bobat, S., MacLennan, I. C. M., Anderson, G., Lane, P. J., Cunningham, A. F.
(2008). Critical Synergy of CD30 and OX40 Signals in CD4 T Cell Homeostasis and Th1 Immunity to Salmonella. J. Immunol.
180: 2824-2829
[Abstract]
[Full Text]
-
Alaniz, R. C., Deatherage, B. L., Lara, J. C., Cookson, B. T.
(2007). Membrane Vesicles Are Immunogenic Facsimiles of Salmonella typhimurium That Potently Activate Dendritic Cells, Prime B and T Cell Responses, and Stimulate Protective Immunity In Vivo. J. Immunol.
179: 7692-7701
[Abstract]
[Full Text]
-
Bitsaktsis, C., Nandi, B., Racine, R., MacNamara, K. C., Winslow, G.
(2007). T-Cell-Independent Humoral Immunity Is Sufficient for Protection against Fatal Intracellular Ehrlichia Infection. Infect. Immun.
75: 4933-4941
[Abstract]
[Full Text]
-
Cunningham, A. F., Gaspal, F., Serre, K., Mohr, E., Henderson, I. R., Scott-Tucker, A., Kenny, S. M., Khan, M., Toellner, K.-M., Lane, P. J. L., MacLennan, I. C. M.
(2007). Salmonella Induces a Switched Antibody Response without Germinal Centers That Impedes the Extracellular Spread of Infection. J. Immunol.
178: 6200-6207
[Abstract]
[Full Text]
-
Srinivasan, A., Salazar-Gonzalez, R.-M., Jarcho, M., Sandau, M. M., Lefrancois, L., McSorley, S. J.
(2007). Innate Immune Activation of CD4 T Cells in Salmonella-Infected Mice Is Dependent on IL-18. J. Immunol.
178: 6342-6349
[Abstract]
[Full Text]
-
Srinivasan, A., McSorley, S. J.
(2007). Exposure to LPS suppresses CD4+ T cell cytokine production in Salmonella-infected mice and exacerbates murine typhoid. J. Leukoc. Biol.
81: 403-411
[Abstract]
[Full Text]
-
Huntley, J. F., Conley, P. G., Hagman, K. E., Norgard, M. V.
(2007). Characterization of Francisella tularensis Outer Membrane Proteins. J. Bacteriol.
189: 561-574
[Abstract]
[Full Text]
-
Alaniz, R. C., Cummings, L. A., Bergman, M. A., Rassoulian-Barrett, S. L., Cookson, B. T.
(2006). Salmonella typhimurium Coordinately Regulates FliC Location and Reduces Dendritic Cell Activation and Antigen Presentation to CD4+ T cells. J. Immunol.
177: 3983-3993
[Abstract]
[Full Text]
-
Sanders, C. J., Yu, Y., Moore, D. A. III, Williams, I. R., Gewirtz, A. T.
(2006). Humoral immune response to flagellin requires T cells and activation of innate immunity.. J. Immunol.
177: 2810-2818
[Abstract]
[Full Text]
-
al-Ramadi, B. K., Fernandez-Cabezudo, M. J., Ullah, A., El-Hasasna, H., Flavell, R. A.
(2006). CD154 Is Essential for Protective Immunity in Experimental Salmonella Infection: Evidence for a Dual Role in Innate and Adaptive Immune Responses. J. Immunol.
176: 496-506
[Abstract]
[Full Text]
-
Yager, E., Bitsaktsis, C., Nandi, B., McBride, J. W., Winslow, G.
(2005). Essential Role for Humoral Immunity during Ehrlichia Infection in Immunocompetent Mice. Infect. Immun.
73: 8009-8016
[Abstract]
[Full Text]
-
Fernandez-Cabezudo, M. J., Ullah, A., Flavell, R. A., al-Ramadi, B. K.
(2005). Evidence for the requirement for CD40--CD154 interactions in resistance to infections with attenuated Salmonella. Innate Immunity
11: 395-399
[Abstract]
-
Bergman, M. A., Cummings, L. A., Alaniz, R. C., Mayeda, L., Fellnerova, I., Cookson, B. T.
(2005). CD4+-T-Cell Responses Generated during Murine Salmonella enterica Serovar Typhimurium Infection Are Directed towards Multiple Epitopes within the Natural Antigen FliC. Infect. Immun.
73: 7226-7235
[Abstract]
[Full Text]
-
Ravindran, R., Foley, J., Stoklasek, T., Glimcher, L. H., McSorley, S. J.
(2005). Expression of T-bet by CD4 T Cells Is Essential for Resistance to Salmonella Infection. J. Immunol.
175: 4603-4610
[Abstract]
[Full Text]
-
Garcia, C. A., Martin, M., Michalek, S. M.
(2004). Role of B7 Costimulatory Molecules in Mediating Systemic and Mucosal Antibody Responses to Attenuated Salmonella enterica Serovar Typhimurium and Its Cloned Antigen. Infect. Immun.
72: 5824-5831
[Abstract]
[Full Text]
-
Tobar, J. A., Gonzalez, P. A., Kalergis, A. M.
(2004). Salmonella Escape from Antigen Presentation Can Be Overcome by Targeting Bacteria to Fc{gamma} Receptors on Dendritic Cells. J. Immunol.
173: 4058-4065
[Abstract]
[Full Text]
-
Srinivasan, A., Foley, J., Ravindran, R., McSorley, S. J.
(2004). Low-Dose Salmonella Infection Evades Activation of Flagellin-Specific CD4 T Cells. J. Immunol.
173: 4091-4099
[Abstract]
[Full Text]
-
Levin, M. L., Coble, D. J., Ross, D. E.
(2004). Reinfection with Anaplasma phagocytophilum in BALB/c Mice and Cross-Protection between Two Sympatric Isolates. Infect. Immun.
72: 4723-4730
[Abstract]
[Full Text]
-
Motameni, A.-R. T., Juncadella, I. J., Ananthanarayanan, S. K., Hedrick, M. N., Huet-Hudson, Y., Anguita, J.
(2004). Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants. Infect. Immun.
72: 3638-3642
[Abstract]
[Full Text]
-
Li, J. S.-y., Winslow, G. M.
(2003). Survival, Replication, and Antibody Susceptibility of Ehrlichia chaffeensis outside of Host Cells. Infect. Immun.
71: 4229-4237
[Abstract]
[Full Text]
-
Mastroeni,, P., Menager, N.
(2003). Development of acquired immunity to Salmonella. J Med Microbiol
52: 453-459
[Abstract]
[Full Text]
-
Matsui, H., Suzuki, M., Isshiki, Y., Kodama, C., Eguchi, M., Kikuchi, Y., Motokawa, K., Takaya, A., Tomoyasu, T., Yamamoto, T.
(2003). Oral Immunization with ATP-Dependent Protease-Deficient Mutants Protects Mice against Subsequent Oral Challenge with Virulent Salmonella enterica Serovar Typhimurium. Infect. Immun.
71: 30-39
[Abstract]
[Full Text]