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Infection and Immunity, June 2000, p. 3720-3723, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Gamma Interferon Is Essential for Clearing Mycobacterium genavense Infection

Stefan Ehlers1,* and Elvira Richter2

Division of Molecular Infection Biology1 and National Reference Center for Mycobacteria,2 Research Center Borstel, D-23845 Borstel, Germany

Received 7 December 1999/Returned for modification 14 February 2000/Accepted 16 March 2000

Factors determining the in vivo replication of the opportunistic pathogen Mycobacterium genavense are largely unknown. Following intravenous injection of a patient isolate, M. genavense could not be recovered by culture or detected by PCR in the livers or spleens of infected BALB/c mice. In contrast, M. genavense was found to chronically persist and multiply in the livers and spleens of intravenously infected syngeneic gamma-interferon-gene-deficient (GKO) mice as evidenced by acid-fast stains of infected tissues and recovery by both PCR and liquid culture following organ homogenization. In GKO mice, M. genavense elicited a chronic inflammatory response, resulting in marked splenomegaly and extensive lymphadenopathy. Granulomatous lesions in the livers of GKO mice were diffuse, were composed of monocytes, neutrophils, and CD3+ cells, and were histochemically negative for inducible nitric oxide synthase.

* Corresponding author. Mailing address: Division of Molecular Infection Biology, Research Center Borstel, Parkallee 22, D-23845 Borstel, Germany. Phone: 49-4537-188481. Fax: 49-4537-188686. E-mail: sehlers{at}fz-borstel.de.

Infection and Immunity, June 2000, p. 3720-3723, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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