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Infection and Immunity, June 2000, p. 3724-3726, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Do Kinetics of the Humoral Response to Cryptococcus neoformans Proteins during Murine Cryptococcosis Reflect Outcome?

Segolene Neuville, Olivier Lortholary, and Francoise Dromer*

Unité de Mycologie, Institut Pasteur, Paris Cedex 15, France

Received 11 January 2000/Returned for modification 8 February 2000/Accepted 9 March 2000

The kinetics of the humoral response to Cryptococcus neoformans proteins were studied in outbred mice infected with isolate NIH52D. Future nonsurvivors had earlier and stronger (i.e., more bands recognized) humoral responses than survivors. In addition, antibodies to a 56- to 60-kDa membrane antigen and to a 39- to 40-kDa cytosolic antigen were detected more frequently in samples from future nonsurvivors and from survivors, respectively (P < 0.05).

* Corresponding author. Mailing address: Unité de Mycologie, Institut Pasteur, 25, rue du Dr.-Roux, 75724 Paris Cedex 15, France. Phone: 33 1 40 61 33 89. Fax: 33 1 45 68 84 20. E-mail: dromer{at}pasteur.fr.

Infection and Immunity, June 2000, p. 3724-3726, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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