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Infection and Immunity, June 2000, p. 3736-3739, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Interaction of Human Phagocytes with Pigmentless Aspergillus Conidia

Bernhard Jahn,1,* Fatima Boukhallouk,1 Johannes Lotz,2 Kim Langfelder,3 Gerhard Wanner,4 and Axel A. Brakhage3

Institut für Medizinische Mikrobiologie und Hygiene1 and Institut für Klinische Chemie und Laboratoriumsmedizin des Klinikums,2 Johannes Gutenberg-Universität Mainz, D-55101 Mainz, Institut für Mikrobiologie und Genetik, Technische Universität Darmstadt, D-64287 Darmstadt,3 and Botanisches Institut, Universität München, D-80638 Munich,4 Germany

Received 1 November 1999/Returned for modification 20 January 2000/Accepted 14 March 2000

A defect in the pksP gene of Aspergillus fumigatus is associated with the loss of conidial pigmentation, a profound change of the conidial surface structure, and reduced virulence. The structural change of the conidial surface structure was not observed in similar A. nidulans wA mutants. Our data indicate that the pigment of both species is important for scavenging reactive oxygen species and for protection of conidia against oxidative damage.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Hygiene, Hochhaus am Augustusplatz, D-55101 Mainz, Germany. Phone: 49-6131-39-37376. Fax: 49-6131-39-22359. E-mail: bjahn{at}mail.uni-mainz.de.

Infection and Immunity, June 2000, p. 3736-3739, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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