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Infection and Immunity, June 2000, p. 3740-3743, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Detection of 23 Immunogenic Pneumococcal Proteins Using Convalescent-Phase Serum

Gregor Zysk,1,* Roger J. M. Bongaerts,1 Elke ten Thoren,1 Gesina Bethe,1 Regine Hakenbeck,2 and Hans-Peter Heinz1

Department of Medical Microbiology and Virology, University of Duesseldorf, Duesseldorf,1 and Department of Microbiology, University of Kaiserslautern, Kaiserslautern,2 Germany

Received 29 November 1999/Accepted 29 February 2000

A genomic expression library of Streptococcus pneumoniae was screened with a convalescent-phase serum for immunoreactive proteins. Six known and 17 unknown pneumococcal proteins were detected. Five of the known proteins were surface-located virulence factors, and eight of the unknown proteins were putative membrane proteins.

* Corresponding author. Mailing address: Department of Medical Microbiology and Virology, University of Duesseldorf, Geb. 22.21/U1, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany. Phone and Fax: 49-211-8112496. E-mail: zysk{at}uni-duesseldorf.de.

Infection and Immunity, June 2000, p. 3740-3743, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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