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Infection and Immunity, June 2000, p. 3744-3747, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Salmonella enterica Serovars Typhimurium and Dublin Can Lyse Macrophages by a Mechanism Distinct from Apoptosis

Patricia R. Watson, Anne V. Gautier,dagger Sue M. Paulin, A. Patricia Bland, Philip W. Jones, and Timothy S. Wallis*

Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom

Received 9 December 1999/Returned for modification 10 February 2000/Accepted 28 February 2000

Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis was dependent on a subset of caspases and an intact sipB gene.

* Corresponding author. Mailing address: Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom. Phone: 44 1635 577230. Fax: 44 1635 577263. E-mail: timothy.wallis{at}bbsrc.ac.uk.

dagger Present address: Unité de Mycoplasmologie-Bactériologie, Agence Française de Sécurité Sanitaire des Aliments, Zoopôle Les Croix BP53, 22440 Ploufgragan, France.

Infection and Immunity, June 2000, p. 3744-3747, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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