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Infection and Immunity, June 2000, p. 3748-3753, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Administration of Endotoxin Associated with Lipopolysaccharide Tolerance Protects Mice against Fungal Infection

Naïma Rayhane,1 Catherine Fitting,1 Olivier Lortholary,2 Francoise Dromer,2 and Jean-Marc Cavaillon1,*

Unité d'Immuno-Allergie1 and Unité de Mycologie,2 Institut Pasteur, 75015 Paris, France

Received 5 January 2000/Returned for modification 1 March 2000/Accepted 10 March 2000

Lipopolysaccharide (LPS) pretreatment of mice resulted in a significantly enhanced survival after disseminated Cryptococcus neoformans infection. The survival was associated with reduced fungal burden in tissues. LPS-pretreated mice had lower levels of cytokines in blood, spleen, and lungs and higher levels in brain. Pentoxifylline abolished the beneficial effect of LPS pretreatment.

* Corresponding author. Mailing address: Unité d'Immuno-Allergie, Institut Pasteur, 28 rue Dr. Roux, 75015 Paris, France. Phone: 33 1 45 68 82 38. Fax: 33 1 40 61 31 60. E-mail: jmcavail{at}pasteur.fr.

Infection and Immunity, June 2000, p. 3748-3753, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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