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Infection and Immunity, June 2000, p. 3748-3753, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Administration of Endotoxin Associated with Lipopolysaccharide
Tolerance Protects Mice against Fungal Infection
Naïma
Rayhane,1
Catherine
Fitting,1
Olivier
Lortholary,2
Francoise
Dromer,2 and
Jean-Marc
Cavaillon1,*
Unité
d'Immuno-Allergie1 and Unité de
Mycologie,2 Institut Pasteur, 75015 Paris,
France
Received 5 January 2000/Returned for modification 1 March
2000/Accepted 10 March 2000
Lipopolysaccharide (LPS) pretreatment of mice resulted in a
significantly enhanced survival after disseminated Cryptococcus neoformans infection. The survival was associated with reduced fungal burden in tissues. LPS-pretreated mice had lower levels of
cytokines in blood, spleen, and lungs and higher levels in brain.
Pentoxifylline abolished the beneficial effect of LPS pretreatment.
*
Corresponding author. Mailing address: Unité
d'Immuno-Allergie, Institut Pasteur, 28 rue Dr. Roux, 75015 Paris,
France. Phone: 33 1 45 68 82 38. Fax: 33 1 40 61 31 60. E-mail:
jmcavail{at}pasteur.fr.
Infection and Immunity, June 2000, p. 3748-3753, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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