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Infection and Immunity, June 2000, p. 3768-3771, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Mutation of waaN Reduces Salmonella enterica Serovar Typhimurium-Induced Enteritis and Net Secretion of Type III Secretion System 1-Dependent Proteins

Patricia R. Watson,1 Annette Benmore,1 Shahid A. Khan,2 Philip W. Jones,1 Duncan J. Maskell,2 and Timothy S. Wallis1,*

Institute for Animal Health, Newbury, Berkshire RG20 7NN,1 and Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES,2 United Kingdom

Received 13 December 1999/Returned for modification 2 February 2000/Accepted 17 March 2000

Mutation of waaN, a gene involved in lipid A biosynthesis, reduced enteropathogenic responses induced by Salmonella enterica serovar Typhimurium in bovine ligated ileal loops. However, the secretion of key virulence determinants was also reduced, and therefore the reduction in enteropathogenicity cannot be solely attributed to a reduction in biological activity of lipid A.

* Corresponding author. Mailing address: Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. Phone: 44 1635 577230. Fax: 44 1635 577263. E-mail: timothy.wallis{at}bbsrc.ac.uk.

Infection and Immunity, June 2000, p. 3768-3771, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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