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Infection and Immunity, June 2000, p. 3768-3771, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Mutation of waaN Reduces
Salmonella enterica Serovar Typhimurium-Induced Enteritis
and Net Secretion of Type III Secretion System 1-Dependent
Proteins
Patricia R.
Watson,1
Annette
Benmore,1
Shahid A.
Khan,2
Philip W.
Jones,1
Duncan J.
Maskell,2 and
Timothy
S.
Wallis1,*
Institute for Animal Health, Newbury,
Berkshire RG20 7NN,1 and Centre for
Veterinary Science, Department of Clinical Veterinary Medicine,
University of Cambridge, Cambridge CB3 0ES,2
United Kingdom
Received 13 December 1999/Returned for modification 2 February
2000/Accepted 17 March 2000
Mutation of waaN, a gene involved in lipid A
biosynthesis, reduced enteropathogenic responses induced by
Salmonella enterica serovar Typhimurium in bovine ligated
ileal loops. However, the secretion of key virulence determinants was
also reduced, and therefore the reduction in enteropathogenicity cannot
be solely attributed to a reduction in biological activity of lipid A.
*
Corresponding author. Mailing address: Institute for
Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. Phone: 44 1635 577230. Fax: 44 1635 577263. E-mail:
timothy.wallis{at}bbsrc.ac.uk.
Infection and Immunity, June 2000, p. 3768-3771, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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