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Infection and Immunity, June 2000, p. 3776-3779, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The Collagen-Binding Adhesin Is a Virulence Factor in Staphylococcus aureus Keratitis

Marcus N. Rhem,1 Elizabeth M. Lech,1 Joseph M. Patti,2,dagger Damien McDevitt,2,Dagger Magnus Höök,2 Dan B. Jones,1 and Kirk R. Wilhelmus1,*

Sid W. Richardson Ocular Microbiology Laboratory, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine,1 and Center for Extracellular Matrix Biology, Albert B. Alkek Institute of Biosciences and Technology, Texas A&M University,2 Houston, Texas

Received 24 January 2000/Returned for modification 1 March 2000/Accepted 23 March 2000

A collagen-binding strain of Staphylococcus aureus produced suppurative inflammation in a rabbit model of soft contact lens-associated bacterial keratitis more often than its collagen-binding-negative isogenic mutant. Reintroduction of the cna gene on a multicopy plasmid into the mutant helped it regain its corneal adherence and infectivity. The topical application of a collagen-binding peptide before bacterial challenge decreased S. aureus adherence to deepithelialized corneas. These data suggest that the collagen-binding adhesin is involved in the pathogenesis of S. aureus infection of the cornea.

* Corresponding author. Mailing address: 6565 Fannin St., Suite NC205, Houston, TX 77030. Phone: (713) 798-5952. Fax: (713) 798-4142. E-mail: kirkw{at}bcm.tmc.edu.

dagger Present address: Inhibitex, Inc., Alpharetta, GA 30004.

Dagger Present address: Microbiology Department, SmithKline Beecham, Collegeville, PA 19426.

Infection and Immunity, June 2000, p. 3776-3779, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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