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Infection and Immunity, June 2000, p. 3784-3786, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Reduced Transendothelial Migration of Monocytes Infected by Coxiella burnetii

Jérôme Dellacasagrande,1 Pierre A. Moulin,1,2 Catherine Guilianelli,2 Christian Capo,1 Didier Raoult,1 Georges E. Grau,1,2 and Jean-Louis Mege1,*

Unité des Rickettsies, Université de la Méditerranée, CNRS UPRESA 6020, Faculté de Médecine,1 and Laboratoire d'Hématologie et d'Immunologie, UFR de Pharmacie,2 13385 Marseille Cedex 05, France

Received 1 December 1999/Returned for modification 26 January 2000/Accepted 23 March 2000

The migratory properties of THP1 monocytes infected by Coxiella burnetii were determined in a transmigration assay across a human microvascular endothelial cell monolayer. Transendothelial migration of monocytes infected by virulent, but not avirulent, C. burnetii was inhibited. This inhibition was observed in spite of conserved adherence properties of infected monocytes.

* Corresponding author. Mailing address: Unité des Rickettsies, Centre National de la Recherche Scientifique UPRESA 6020, Faculté de Médecine, 27 Bd. Jean Moulin, 13385 Marseille Cedex 05, France. Phone: (33) 4 91 32 43 75. Fax: (33) 4 91 83 03 90. E-mail: Jean-Louis.Mege{at}medecine.univ-mrs.fr.

Infection and Immunity, June 2000, p. 3784-3786, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Drevets, D. A., Leenen, P. J. M., Greenfield, R. A. (2004). Invasion of the Central Nervous System by Intracellular Bacteria. Clin. Microbiol. Rev. 17: 323-347 [Abstract] [Full Text]  
  • Dellacasagrande, J., Ghigo, E., Raoult, D., Capo, C., Mege, J.-L. (2002). IFN-{gamma}-Induced Apoptosis and Microbicidal Activity in Monocytes Harboring the Intracellular Bacterium Coxiella burnetii Require Membrane TNF and Homotypic Cell Adherence. J. Immunol. 169: 6309-6315 [Abstract] [Full Text]  


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