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Infection and Immunity, July 2000, p. 4327-4330, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Binding and Activation of Human Plasminogen by Mycobacterium tuberculosis

Verónica Monroy,1 Angelica Amador,2 Blanca Ruiz,1 Patricia Espinoza-Cueto,2 Wendy Xolalpa,1 Raul Mancilla,2 and Clara Espitia2,*

Departamento de Inmunología2 and Departamento de Biología Molecular,1 Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, C.P. 04510 Mexico City D.F., Mexico

Received 16 August 1999/Returned for modification 15 February 2000/Accepted 12 April 2000

The first evidence of the interaction of Mycobacterium tuberculosis with the plasminogen system is herein reported. By FACScan analysis and affinity blotting, lysine-dependent binding of plasminogen to M. tuberculosis was demonstrated. The binding molecules were 30-, 60-, and 66-kDa proteins present in cell wall and soluble protein extracts. The activation of plasminogen, which occurred only in presence of fibrin and was not inhibited by the host serpin, alpha 2-antiplasmin, was also demonstrated.

* Corresponding author. Mailing address: Instituto de Investigaciones Biomédicas, Departamento de Inmunología, Apartado Postal 70-228, 04510 D.F. Mexico City D.F., Mexico. Phone: (525)6223884. Fax: (525)6223369. E-mail: espitia{at}servidor.unam.mx.

Infection and Immunity, July 2000, p. 4327-4330, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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